Biological Features of Tcm : A New Trypanosoma Cruzi Isolate from Argentina (Dtu V) Displaying Slow Growth, Cardiac Tropism, and Susceptibility to Benznidazole
Trypanosoma cruzi , the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified in seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat). Although isolates and strains that belong to a particular group can share some biological attributes as geographic distribution, other like virulence or response to treatment can be highly variable. In this work, we describe the isolation and characterization of a new T. cruzi strain from a blood sample of a chronic patient from Mendoza city, Argentina (named TcM). We have studied its genetic background and biological features in comparison with the T. cruzi Y strain that belongs to DTU TcII. We have observed that TcM is a slow-growing strain with tendency to develop chronic infections in mice, with high tropism to muscular tissues and more susceptible to benznidazole than the Y strain. In contrast, Y strain behaved as an acute strain that can infect different type of cells and tissues. This work added new knowledge about the biological behavior of a strain belonging to TcV, a linage frequently found in human and animal isolates from the Southern countries of America. The study of the biological attributes of the strain in addition to its clinical performance will help to improve the management of the patient with Chagas disease in the future
Year of publication: |
[2022]
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Authors: | Romano, Patricia Silvia ; Martinez, Santiago José ; Nardella, Gonzalo Nicolás ; Rodríguez, Matías Exequiel ; Rivero, Cynthia Vanesa ; Agüero, Fernán |
Publisher: |
[S.l.] : SSRN |
Subject: | Argentinien | Argentina | Wirtschaftswachstum | Economic growth |
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