This study was conducted on the premise that if quality business information is provided to business enterprises, socio-economic transformation could be achieved. The study emanated from the documented problem where business enterprises in northern Uganda were found to depend on "word of mouth" rather than any meaningful formal mechanism for accessing information efficiently. The aim of the study was, therefore, to design an information system for northern Uganda business enterprises. The study makes use of document analysis, questionnaires and interviews. The Small and Medium scale Enterprises (SMEs), information providers and business policy-makers in northern Uganda constituted the population of the study. The data which was collected was edited and analysed to produce graphs, charts and percentages. The main findings indicate that business activities in northern Uganda are diverse - covering almost the entire sector of the economy. The SMEs need information on finance/capital/loans, local markets, business management skills, appropriate technologies, business competitors and security. They are lagging behind in using Information and Communication Technologies (ICTs). There is a lack of familiarity with changing technology - especially the Internet. Although the SMEs are making a fundamental contribution to Uganda's economy, they face serious challenges, such as insecurity, inadequate electricity, lack of trained information professionals and appropriate technology to access electronic information. The findings further indicate that respondents want business information to be selective to address their needs.The study concludes that the SMEs need an efficient, effective mechanism to provide the required business information. Hence, it is recommended that a business information system (BIS) design be implemented to address their needs. The BIS should provide business information in terms of legal, technical and economic information as well as contact information and management skills. Information should be processed by means of radio broadcasts, the telephone, short text messages, posters, online and CD-ROM formats - as required by the SMEs managers. To facilitate access, BIS should have telephone services; Internet-based services; online small business workshops; business start up assistant; and Talk to BIS services. BIS should have a flexible interface.