Co2 Be a Catalyst? Yes, Evidence from N-Formylation of Aliphatic Amines with Dmf in Presence of Co2
CO 2 was found to serve as an efficient and clean catalyst for the first time in N -formylation of aliphatic amines with DMF for the production of formamides. The DMF- d 7 isotope labeling experiment indicated that the N -formyl group in the target products was originated from DMF rather than CO 2 which truly confirmed the role of CO 2 as a catalyst. It was also found that the formation of carbamate salt intermediate A derived from the reaction of CO 2 with the cyclohexylamine as a catalyst-substrate adduct was the driving force for this reaction, supported by the control experiments and the in situ high-pressure FT-IR spectroscopic analysis. Accordingly, the reaction mechanism over CO 2 -catalyst was proposed, involving the critical formation of carbamate salt intermediate with enhanced nucleophilicity in favor of the attack on carbonyl-group of DMF
Year of publication: |
[2022]
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Authors: | Chen, Xiao-Chao ; Guo, Lin ; Yao, Yin-Qing ; Zhao, Kai-Chun ; Lu, Yong ; Liu, Ye |
Publisher: |
[S.l.] : SSRN |
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