One of the most noticeable trends in XXth-ÕÕIst centuries has become focus of the world community on integration processes. Touching upon such notions as ?European integrational area?, ?globalization?, ?regionalization? and their intercourse one can assume that if an area for integration can be viewed as something akin to environment (milieu), whereas globalization and regionalization represent processes of internal structuration of this environment. Globalization implies recognition of growing interconnectedness of states, nations and societies. It acts as a powerful tool for qualitative changes in integrational area. Proceeding from conceptual approaches of neofunctionalists (E. Haas), integration processes start out from the sphere, which has least hurdles for interaction. Under contemporary circumstances of global cooperation new architecture of integrational areas is being constructed. On the one hand, they are geographically localized and are posed as regional units of measurement. And on the other ? these areas amount to global structures due to their political and economic connections. In this regard understanding of integrational area as a specifically organized one is utterly relevant in the age of globalization. Nature of the European integrational area is embodied in formation of, on the one hand, macroareas, and, on the other hand, in onerous process of attraction and repulsion of separate regions within that area. Within the academic discourse a new concept has come into existence ? global regionalization (regional globalization). Its essence implies combination of globalization and regionalization processes, where local and global co-exist not as mutually excluding processes, rather as a global entity within a local one. Synergy method can be applied for understanding of dialectics of convergence between global and regional entities in evolution of European integrational area. If globalization is viewed as a chaotic and uncontrollable process, whereas regionalization is posed as a factor of self-organization by actors of integration. According to the second law of thermodynamics entropy (i.e. uncertainty and chaos) rises gradually within closed systems. At the same time open-ended systems exhibit properties of self-organization. That is why, openness principle is vital for successful functioning of the European integrational area. This ?transregionality? principle is defined mostly by the ?open regionalism? doctrine, where external globalizational impact will make for internal regionalizational self-organization. Ultimately, one can draw a conclusion that a streak of crises within the European integrational area can be overcome, but only through the way towards global regionalization.