Evaluation of a mean field potential for protein folding with different interaction centers
We use Monte Carlo simulations to analyze the behavior of a family of previously reported, statistically derived, mean field potentials for protein folding (the DFIRE potentials from the Zhou laboratory). The potentials may consider different interaction centers (alpha carbons, beta carbons, or side-chain centroids), depending on the details of the coarse-grained model simulated. The type of association of the helices in different simulated coiled-coil proteins provides interesting information on the real capabilities of these interaction schemes along the sampling of the topological space available to the protein model.
Year of publication: |
2006
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Authors: | Larriva, MarĂa ; de Sancho, David ; Rey, Antonio |
Published in: |
Physica A: Statistical Mechanics and its Applications. - Elsevier, ISSN 0378-4371. - Vol. 371.2006, 2, p. 449-462
|
Publisher: |
Elsevier |
Subject: | Protein folding | Mean field potentials | Simulated annealing | Interaction centers | Coarse-grained models | Coiled coils |
Saved in:
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