Flexible Intelligent Array Patch Based on Synergy of Polyurethane and Nanofiber for Sensitive Monitor and Smart Treatment

Currently, the implantation and health treatment of electronic devices based on adhesion and flexible substrates are widely studied. However, these adhesive layers are usually non-conductive, and how to achieve stable electrical conductivity on flexible substrates remains challenging. Here, a flexible intelligent array patch based on the synergism of polyurethane (PU) and nanofibers (NFs) is fabricated for sensitive monitoring and intelligent treatment. PU as a bonding layer, then polycaprolactone-gelatin NFs is deposited on the PU to form a PU/NF film. Compared to sputtering the gold layer directly on the PU, the nanonetwork by electrospinning shows more stable electrical conductivity. Finally, a loop feedback system is designed on the PU/NF, which integrates the sensor electrode and drug electrode. PU and NFs are mechanically matched and tightly bound, not only conductively stable, but also have excellent elasticity and conformal contact, improving sensor sensitivity and eliminating artifacts. The gold NF strain sensor can respond quickly within 0.15 s and detect even 0.1% tiny strain, which collect subtle physiological signals. The drug electrode was prepared by electroplating polypyrrole on gold NF and loading dexamethasone (DEX). The low-impedance, high-specific surface area drug electrode with nanofiber structure can controllably release 54.9 μg cm -2 within 1 min at 0.6 V, which is about 100 times that of flat glass. This system demonstrates can work on isolated porcine and in vivo rat heart models for cardiac signal detection and drug release functions