Ignored and Undervalued in Public Health : A Systematic Review of Health State Utility Values Associated with Syphilis Infection
Background: Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated with syphilis.Methods: We conducted a systematic review, searching six databases for economic evaluations and primary valuation studies related to syphilis from January 2000 to February 2022. We extracted health state utility values or disability weights, including identification of how these were derived. The study was registered in the international prospective register of systematic reviews (PROSPERO, CRD42021230035). Findings: Of 3277 studies screened, 22 economic evaluations, two primary studies providing condition-specific measures, and 13 burden of disease studies were included. Fifteen economic evaluations reported outcomes as disability-adjusted life years (DALYs) and seven reported quality-adjusted life years (QALYs). Fourteen of 15 economic evaluations that used DALYS based their values on the original Global Burden of Disease (GBD) study from 1990 (published in 1996). For the seven QALY-related economic evaluations, the methodology varied between studies, with some studies using assumptions and others creating utility weights or converting them from disability weights.Interpretation: We found a limited evidence base for the valuation of health states for syphilis, a lack of transparency for the development of existing health state utility values, and inconsistencies in the application of these values to estimate DALYs and QALYs. Further research is required to expand the evidence base so that policymakers can access accurate and well-informed economic evaluations to implement syphilis programs that are cost-effective.Funding: JJO is supported by the Australian National Health and Medical Research Council (NHMRC) Emerging Leader Fellowship (GNT1193955).Declaration of Interest: Some of the authors are present or former staff members of the World Health Organization. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated. All other authors declare no competing interests
Year of publication: |
2022
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Authors: | Miao, Patrick ; Terris-Prestholt, Fern ; Fairley, Christopher K. ; Tucker, Joseph D. ; Wiseman, Virginia ; Mayaud, Philippe ; Zhang, Ying ; Rowley, Jane ; Gottlieb, Sami L. ; Korenromp, Eline ; Watts, Caroline ; Ong, Jason |
Publisher: |
[S.l.] : SSRN |
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