Ontogenetic growth of multicellular tumor spheroids

In ontogenetic growth models, the basal metabolic rate is usually assumed to depend on the individual mass following a power law. Here it is shown that, in the case of multicellular tumor spheroids, the emergence of a necrotic core invalidates this assumption. The implications of this result for spheroid growth are discussed, and a procedure to determine the growth parameters using macroscopic measurements is proposed.

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Year of publication:	2006
Authors:	Condat, C.A. ; Menchón, S.A.
Published in:	Physica A: Statistical Mechanics and its Applications. - Elsevier, ISSN 0378-4371. - Vol. 371.2006, 1, p. 76-79
Publisher:	Elsevier
Subject:	Ontogenetic growth \| Diffusion \| Necrosis \| Multicellular tumor spheroid \| Cancer

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Type of publication:	Article
Source:	RePEc - Research Papers in Economics

Persistent link: https://www.econbiz.de/10011060953