Rotenone Mediated Developmental Toxicity in Drosophila Melanogaster
Rotenone (ROT) is a widely used natural pesticide, and its effect on growth and developmental toxicity remain unclear. In the present study, the effects of ROT exposure on the reproductive structure and function of the female Drosophila melanogaster and third instar larvae were investigated. Exposure to ROT on female Drosophila melanogaster resulted in developmental inhibition and ovarian abnormality, which were evident from the disruptive growth of border cells as well as morphological changes in the orientation of nurse cells during 9th-10th stage of developing egg chamber of Drosophila ovary. Other abnormalities like altered developmental gene expression (Osk, Grk, Nos, Bic-d), inhibition in the kinesin motor protein level (KIF-5B), and increased caspases activities (Caspase 3, 8, & 9) and apoptosis were also observed. Further food intake analysis on third instar larvae confirmed that the ROT is not an antifeedant. Subsequently, ROT treated larvae exhibited behavioural deficits and delay in developmental time. The above findings suggested that the exposure of ROT may have caused developmental toxicity in Drosophila melanogaster
Year of publication: |
[2022]
|
---|---|
Authors: | Kumar, P. Pramod ; Bawani, Saliya S. ; Anandhi, Duraiswamy Usha ; Keelara Veerappa, Harish Prashanth |
Publisher: |
[S.l.] : SSRN |
Saved in:
freely available
Saved in favorites
Similar items by subject
-
Find similar items by using search terms and synonyms from our Thesaurus for Economics (STW).