The Highly Effective Therapy of Ovarian Cancer by Bi-Doped Oxygen-Deficient Batio3 with Enhanced Sono-Piezocatalytic Effects

Ovarian cancer (OC) is the leading cause of death of gynecological malignancy. Sonodynamic therapy (SDT) with high penetration ability and biosafety is considered as a minimally invasive method for the elimination of deep tumor. However, sonosensitizers with high efficiency are still urgently needed. Here, we developed an oxygen defect-rich piezoelectric nanocomposite barium titanate nanocubes with bismuth dope for enhanced sonodynamic ovarian cancer therapy. The oxygen defect engineering decreases the band gap, and Schottky junction modified by Bi nanoparticles effectively enhance the transfer and separation of charge carriers and inhibited the recombination under US irradiation, leading to product more reactive oxygen species (ROS), which significantly enhance the SDT efficiency. The in vitro results demonstrated that Bi doped oxygen-deficient BaTO 3 significantly promote the apoptosis of tumor cells because of the high ROS generation efficiency. RNA sequencing further proved that antitumor activity may be through extracellular matrix disassembly pathway. At last, the in vivo results showed that Bi doped oxygen-deficient BaTO 3 can significantly eliminate ovarian cancer through SDT. This work proposed an oxygen defect-rich piezoelectric nanocomposite as a new kind of sonosensitizer with high SDT efficiency for enhanced sonodynamic ovarian cancer therapy