A Wireless Battery-Less and Moisture-Resistant Packaged Glucose Sensing System Employing Hydrogel-Based Inductive Sensing Technique and Low-Power Asic for Long-Term Glucose Monitoring
A wireless and battery-less glucose sensing system has been demonstrated for future long-term implantable glucose monitoring. The proposed glucose sensing system employs an oscillator-based inductive sensor that detects a volumetric change of a glucose-sensitive hydrogel. A robust 3D-printed moisture-resistant package is used to encapsulate the sensing system for in-vitro characterization. An application-specific integrated circuit (ASIC) is designed to enable in-situ temperature characterization as well as system miniaturization. The overall system dissipates 600 μW and exhibits a dimension of 6 mm x 6 mm x 25 mm. A rotation-insensitive wireless powering scheme has been demonstrated to reliably deliver power to a tube-shaped implantable system. The prototype sensor operated at 190 MHz can be wirelessly powered by a 6.78 MHz RF power source over a distance of 2 cm. The sensor achieves a glucose sensing resolution of 0.025 mM – 0.055 mM within a typical physiological glucose concentration between 4 mM to 10 mM at a typical human body temperature of 37 ºC. The prototype sensor has demonstrated a reliable in-vitro operation for 60 days without noticeable performance degradation
Year of publication: |
[2022]
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Authors: | Yu, Yuechuan ; Nguyen, Tram ; Tathireddy, Prashant ; Roundy, Shad ; Young, Darrin J. |
Publisher: |
[S.l.] : SSRN |
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