The paper examines whether diabetes mellitus leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct...

Abstract The paper considers the properties of and relations between confounding and effect modification from the perspective of causal inference and with a distinction drawn as to how each of these two epidemiologic concepts can be defined both with respect to a distribution of potential...

Abstract Interactions measured on the additive scale are more relevant than multiplicative interaction for assessing public health importance and also more closely related to notions of mechanistic synergism. Most work on sample size and power calculations for interaction have focused on the...