Simulation is widely used to investigate real-world systems in a large number of fields, including clinical trials for drug development, since real trials are costly, frequently fail and may lead to serious side effects. This paper is a survey of the statistical issues arising in these simulated...

(English) In this work the Delphi participative methodology is analyzed, considering and critically discussing the most relevant literature. The main results are reorganized in a strengths and weaknesses scheme. The analysis of Delphi methodology is preceded by a general introduction on the...

Chapter 1: Introduction -- Chapter 2: Healthcare in the 4.0 Era of Digitization -- Chapter 3: One Digital Health.-Chapter 4: Value-Based Healthcare -- Chapter 5: Value Co-creation and Stakeholders’ Engagement -- Chapter 6: The Evolution to Patient Centricity -- Chapter 7: Patient Experience --...