We present a novel maximum-likelihood-based algorithm for estimating the distribution of alignment scores from the scores of unrelated sequences in a database search. Using a new method for measuring the accuracy of p-values, we show that our maximum-likelihood-based algorithm is more accurate...

The order of actions in contests may generate different psychological effects which, in turn, may influence contestants' probabilities to win. The Prouhet-Thue-Morse sequence in which the first 'n' moves is the exact mirror image of the next 'n' moves should theoretically terminate any advantage...